BDBM714632 US20250025459, Compound I-017::US20250127788, Compound I-017::US20260125365, Compound II-0378
SMILES Cc1cncc(-n2c(=O)nc(Nc3cc4cn(C)nc4cc3Cl)n(Cc3ccc(F)c(C#N)c3)c2=O)c1
InChI Key InChIKey=QNLMYJJUQPZSSI-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 714632
Affinity DataIC50: 3.40nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:In this test, an assay buffer consisting of 20 mM Tris-HCl, 100 mM sodium chloride, 1 mM EDTA, 10 mM DTT, and 0.01% BSA is used. For compounds with a...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Preparation of Assay Buffer:In this test, an assay buffer consisting of 20 mM Tris-Hl, 100 mM sodium chloride, 1 mM EDTA, 10 mM DTT, and 0.01% BSA is...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair