BDBM714640 US20250025459, Compound I-025::US20250127788, Compound I-025::US20260125365, Compound I-0429

SMILES Cn1cc2cc(Nc3nc(=O)n(-c4cncc5ccccc45)c(=O)n3Cc3ccc(F)c(C#N)c3)c(F)cc2n1

InChI Key InChIKey=MGZSCAFELIDSHJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 714640   

TargetReplicase polyprotein 1a(2019-nCoV)
Shionogi & Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 714640BDBM714640(US20250025459, Compound I-025 | US20250127788, Com...)
Affinity DataIC50: 100nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Shionogi & Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 714640BDBM714640(US20250025459, Compound I-025 | US20250127788, Com...)
Affinity DataIC50: 100nMAssay Description:In this test, an assay buffer consisting of 20 mM Tris-HCl, 100 mM sodium chloride, 1 mM EDTA, 10 mM DTT, and 0.01% BSA is used. For compounds with a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

US Patent
LigandChemical structure of BindingDB Monomer ID 714640BDBM714640(US20250025459, Compound I-025 | US20250127788, Com...)
Affinity DataIC50: 100nMAssay Description:Preparation of Assay Buffer:In this test, an assay buffer consisting of 20 mM Tris-Hl, 100 mM sodium chloride, 1 mM EDTA, 10 mM DTT, and 0.01% BSA is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent