BDBM715312 US20250026748, Compound 476

SMILES COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1

InChI Key InChIKey=ZAEYDSHIXXLWTJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 715312   

TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human DNA polymerase theta (67 to 970 residues) ATPase activity expressed in Sf9 insect cells incubated for 40 mins by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 200nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) (1 to 899 residues) ATPase activity by NADH oxidation-coupled enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM715312(US20250026748, Compound 476)
Affinity DataIC50: 1.17E+3nMAssay Description:A seven-point semi-log dilution of each test compound (up to 30 NM) or positive control inhibitors for CYP2C9 (up to 1000 nM sulphenazole), CYP2D6 (u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent