BDBM716027 (1R,3S)-4''-Chloro-5''-(3-(4-(cyanomethyl)-3- methylpyridin-2-yl)-2-fluorophenyl)-3-methyl- 1'',2''-dihydrospiro[cyclopentane-1,3''-pyrrolo[2,3- b]pyridine]-3-carbonitrile (1S,3R)-4''-Chloro-5''-(3-(4-(cyanomethyl)-3- methylpyridin-2-yl)-2-fluorophenyl)-3-methyl- 1'',2''-dihydrospiro[cyclopentane-1,3''-pyrrolo[2,3- b]pyridine]-3-carbonitrile::US12208088, Compound 266b

SMILES Cc1c(CC#N)ccnc1-c1cccc(-c2cnc3c(c2Cl)[C@]2(CC[C@@](C)(C#N)C2)CN3)c1F

InChI Key InChIKey=OFKMIJTXPCGYIZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 716027   

LigandPNGBDBM716027((1R,3S)-4'-Chloro-5'-(3-(4-(cyanomethyl)-3- methyl...)
Affinity DataKi:  3.90nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent