BDBM716156 6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(6-(trifluoromethyl)- pyridin-2-yl)cyclohexyl)oxy)- 2-methyl-N-(pyrimidin-4- yl)pyridine-3-sulfonamide::US12209075, Example 51::US20250115576, Example 51

SMILES Cc1nc(O[C@H]2CC[C@H](c3cccc(C(F)(F)F)n3)C[C@@H]2N(C)C)ccc1S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=JPWUVRRFRVTVQO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716156   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716156(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(6-(trifluoro...)
Affinity DataIC50: 0.985nMAssay Description:A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydrogens to generate [3H]compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716156(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(6-(trifluoro...)
Affinity DataIC50: 4.59nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716156(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(6-(trifluoro...)
Affinity DataIC50: 4.59nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent