BDBM716160 2-methyl-6-(((1S,2S,4S)-2- morpholino-4-(3-(trifluoro- methyl)phenyl)cyclohexyl)- oxy)-N-(pyrimidin-4- yl)pyridine-3-sulfonamide::US12209075, Example 55::US20250115576, Example 55

SMILES Cc1nc(O[C@H]2CC[C@H](c3cccc(C(F)(F)F)c3)C[C@@H]2N2CCOCC2)ccc1S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=WQFJSXQCLVOAKW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716160   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716160(2-methyl-6-(((1S,2S,4S)-2- morpholino-4-(3-(triflu...)
Affinity DataIC50: 0.527nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716160(2-methyl-6-(((1S,2S,4S)-2- morpholino-4-(3-(triflu...)
Affinity DataIC50: 0.527nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716160(2-methyl-6-(((1S,2S,4S)-2- morpholino-4-(3-(triflu...)
Affinity DataIC50: 1.72nMAssay Description:A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydrogens to generate [3H]compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent