BDBM716163 6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(3-methyl-5- (trifluoromethyl)phenyl)- cyclohexyl)oxy)-2-methyl-N- (pyrimidin-4-yl)pyridine-3- sulfonamide::US12209075, Example 58::US20250115576, Example 58

SMILES Cc1cc([C@H]2CC[C@H](Oc3ccc(S(=O)(=O)Nc4ccncn4)c(C)n3)[C@@H](N(C)C)C2)cc(C(F)(F)F)c1

InChI Key InChIKey=TURAEZDSWZCNQG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716163   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716163(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(3-methyl-5- ...)
Affinity DataIC50: 0.351nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716163(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(3-methyl-5- ...)
Affinity DataIC50: 0.351nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716163(6-(((1S,2S,4S)-2-(dimethyl- amino)-4-(3-methyl-5- ...)
Affinity DataIC50: 2.86nMAssay Description:A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydrogens to generate [3H]compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent