BDBM716482 US20250034112, Compound 21

SMILES Nc4nc(Oc2ccc(NC(=O)C[C@@H](NC(=O)c1ccccc1)C(=O)O)cc2)c3cc[nH]c3n4

InChI Key InChIKey=IKNVAKNHQGSWLV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716482   

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716482(US20250034112, Compound 21)
Affinity DataKd:  96nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM716482(US20250034112, Compound 21)
Affinity DataIC50: 96nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812,V617F](Human)
Yale University

US Patent
LigandPNGBDBM716482(US20250034112, Compound 21)
Affinity DataIC50: 106nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM716482(US20250034112, Compound 21)
Affinity DataIC50: 3.22E+4nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent