BDBM716807 US20250034135, Compound 245

SMILES CC(C)c1ccccc1[C@@H]1CN(Cc2ccc(CN3CCCC3)cc2)CCN1C1CC2(CCN(c3cc(Oc4cnc5[nH]ccc5c4)c(C(=O)NS(=O)(=O)c4ccc(NCC5(F)CCOCC5)c([N+](=O)[O-])c4)cc3F)CC2)C1

InChI Key InChIKey=FILNNFYGDWHHBJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716807   

TargetApoptosis regulator Bcl-2 [G101V](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716807(US20250034135, Compound 245)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (G101V) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716807(US20250034135, Compound 245)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 (D103Y) and pro-apoptotic protein Bim was performed using Homogeneous Time-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716807(US20250034135, Compound 245)
Affinity DataIC50: 10nMAssay Description:The detection of the binding ability between anti-apoptotic protein BCL2 and pro-apoptotic protein Bim was performed using Homogeneous Time-Resolved ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Hangzhou Healzen Therapeutics Co.

US Patent
LigandPNGBDBM716807(US20250034135, Compound 245)
Affinity DataIC50: 500nMAssay Description:In a white shallow 384-well plate, a total reaction volume was 10 μL. Specifically, it included 2 μL of the compound to be tested (2% DMSO), 4 L His-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent