BDBM717519 US20250034165, Example 56

SMILES CNCCNc1ccc2c(c1)N1C[C@H](C3CC3)CCCOc3c(cnn3C)-c3cc(cc(C)n3)C(=O)/N=C/1C2

InChI Key InChIKey=OYKKZWGJULNFRI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 717519   

TargetEpidermal growth factor receptor [1-18,20-745,751-1210,T790M](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandChemical structure of BindingDB Monomer ID 717519BDBM717519(US20250034165, Example 56)
Affinity DataIC50: 0.0140nMAssay Description:A 50 ng/μL EGFR (d746-750/T790M, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandChemical structure of BindingDB Monomer ID 717519BDBM717519(US20250034165, Example 56)
Affinity DataIC50: 0.0160nMAssay Description:A 50 ng/μL EGFR (L858R/T790M, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 20),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-745,751-1210,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandChemical structure of BindingDB Monomer ID 717519BDBM717519(US20250034165, Example 56)
Affinity DataIC50: 0.0210nMAssay Description:A 50 ng/μL EGFR (d746-750/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Twe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandChemical structure of BindingDB Monomer ID 717519BDBM717519(US20250034165, Example 56)
Affinity DataIC50: 0.0220nMAssay Description:A 50 ng/μL EGFR (L858R/T790M/C797S, BPS) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandChemical structure of BindingDB Monomer ID 717519BDBM717519(US20250034165, Example 56)
Affinity DataIC50: 0.640nMAssay Description:A 50 ng/μL EGFR (WT, Carna) stock solution was diluted with a kinase buffer (50 mM HEPES, 10 mM MgCl2, 2 mM DTT, 1 mM EGTA, 0.01% Tween 20), and 6 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent