BDBM717920 US20250042857, Example B-21

SMILES C[C@@H](Nc1ccnc2cnc(N3CCOCC3)cc12)c1cccc(C(F)F)c1F

InChI Key InChIKey=PXKAELQVWYOADZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717920   

LigandPNGBDBM717920(US20250042857, Example B-21)
Affinity DataIC50: 7nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Haihe Biopharma Co.

US Patent
LigandPNGBDBM717920(US20250042857, Example B-21)
Affinity DataIC50: 100nMAssay Description:Experimental reagents: KRASG12C/SOS binding kit (Cisbio, cat. 63ADK000CB16PEG); DMSO (Sigma, cat. D8418-1L); and 384-well white plate (PerkinElmer, c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent