BDBM718910 6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S,Z)-2- (fluoromethylene)tetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)- 5a,6,7,8,9,10-hexahydro-5H-6,9- epiminoazepino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin- 2-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 2

SMILES Cc8cc(N)nc(c7c(F)c3nc(OC[C@@]12CCCN1C/C(=C/F)C2)nc4c3c(OC[C@@H]5[C@@H]6CC[C@H](CN45)N6)c7Cl)c8C(F)(F)F

InChI Key InChIKey=HEVDVSRQHBFBDL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718910   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718910(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S,Z)-2-...)
Affinity DataIC50: 0.389nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718910(6-((2R,5aS,6S,9R)-3-chloro-1- fluoro-13-(((S,Z)-2-...)
Affinity DataIC50: 2.55nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent