BDBM718912 1-((2R,5aS,6S,9R)-2-(6-amino-4- methyl-3-(trifluoromethyl)pyridin- 2-yl)-3-chloro-1-fluoro-13-(((S)-2- methylenetetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)- 5a,6,7,8,9,10-hexahydro-5H-6,9- epiminoazepino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin-15- yl)ethan-1-one::US20250042919, Compound 4

SMILES C=C1CN2CCC[C@@]2(COc2nc3c4c(c(Cl)c(-c5nc(N)cc(C)c5C(F)(F)F)c(F)c4n2)OC[C@@H]2[C@@H]4CC[C@H](CN32)N4C(C)=O)C1

InChI Key InChIKey=YKHNKDBEZCNLMF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718912   

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718912(1-((2R,5aS,6S,9R)-2-(6-amino-4- methyl-3-(trifluor...)
Affinity DataIC50: 3.34nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718912(1-((2R,5aS,6S,9R)-2-(6-amino-4- methyl-3-(trifluor...)
Affinity DataIC50: 7.64nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent