BDBM718921 6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2,2-difluorotetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)-1- fluoro-5a,6,7,8,9,10-hexahydro- 5H-6,9- epiminoazepino[2'',1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin- 2-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 12

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OC[C@@]56CCCN5CC(F)(F)C6)nc4c2F)N2C[C@H]4CC[C@H](N4)[C@H]2CO3)c1C(F)(F)F

InChI Key InChIKey=REMPGFQEXMTOEM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718921   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718921(6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2,2-difluorot...)
Affinity DataIC50: 2.15nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718921(6-((2R,5aS,6S,9R)-3-chloro-13- (((S)-2,2-difluorot...)
Affinity DataIC50: 264nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent