BDBM718927 (5aS,6S,9R)-3-chloro-2-(6-fluoro- 1-methyl-1H-indazol-7-yl)-13- (((S)-2-methylenetetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)- 5a,6,7,8,9,10-hexahydro-5H-6,9- epiminoazepino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazoline::US20250042919, Compound 16B

SMILES C=C1CN2CCC[C@@]2(COc2nc3c4c(c(Cl)c(-c5c(F)ccc6cnn(C)c56)cc4n2)OC[C@@H]2[C@@H]4CC[C@H](CN32)N4)C1

InChI Key InChIKey=KALOTCMNEWGZKZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718927   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718927((5aS,6S,9R)-3-chloro-2-(6-fluoro- 1-methyl-1H-inda...)
Affinity DataIC50: 0.710nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718927((5aS,6S,9R)-3-chloro-2-(6-fluoro- 1-methyl-1H-inda...)
Affinity DataIC50: 40nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent