BDBM718961 US20250042919, Compound 43B

SMILES COn9ncc8ccc(F)c(c7c(F)c3nc(OC[C@@]12CCCN1C[C@H](F)C2)nc4c3c(O[C@@H](C)[C@@H]5[C@@H]6CC[C@H](CN45)N6)c7Cl)c89

InChI Key InChIKey=MJIPVKIYNXCNBW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718961   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718961(US20250042919, Compound 43B)
Affinity DataIC50: 0.330nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718961(US20250042919, Compound 43B)
Affinity DataIC50: 61.4nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent