BDBM718962 2-((5S,5aS,6S,9R)-3-Chloro-1- fluoro-13-(((2R,7aS)-2- fluorotetrahydro-1H-pyrrolizin- 7a(5H)-yl)methoxy)-5-methyl- 5a,6,7,8,9,10-hexahydro-5H-6,9- epiminoazepino[2'',1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin-2- yl)phenol::US20250042919, Compound 44

SMILES C[C@@H]1Oc2c(Cl)c(-c3ccccc3O)c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(c23)N2C[C@H]3CC[C@H](N3)[C@@H]12

InChI Key InChIKey=RAIGVTUUBXJVFT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718962   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718962(2-((5S,5aS,6S,9R)-3-Chloro-1- fluoro-13-(((2R,7aS)...)
Affinity DataIC50: 1.81nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718962(2-((5S,5aS,6S,9R)-3-Chloro-1- fluoro-13-(((2R,7aS)...)
Affinity DataIC50: 179nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent