BDBM718997 (2S,4R)-1-[(2S)-2-[3-(2-[2-[2-(4-[2-[(4-[[4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[14-oxa-2,4,10-triazatricyclo[7.5.0.0{circumflex over ( )}[3,7]]tetradeca-1(9),2,5,7-tetraen-10-yl]phenyl]formamidosulfonyl]-2-nitrophenyl)amino]ethyl]piperazin-1-yl)ethoxy]ethoxy]ethoxy)propanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide::US12220419, Example 54

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)C(C)(C)CCNC(=O)CCOCCOCCOCCN2CCN(CCNc3cc(NS(=O)(=O)c4ccc(N5CCN(CC6=C(c7ccccc7)CC(C)(C)CC6)CC5)cc4N4CCCC(=O)c5nc6[nH]ccc6cc54)ccc3[N+](=O)[O-])CC2)cc1

InChI Key InChIKey=UCKFIIZITNZMOT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 718997   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM718997((2S,4R)-1-[(2S)-2-[3-(2-[2-[2-(4-[2-[(4-[[4-(4-[[2...)
Affinity DataIC50: 0.600nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
US Patent