BDBM719423 3-chloro-4-((1S,2S)-2-(5-chloro-2-oxo-1,2-dihydropyridin-3-yl)cyclopropyl)-3'-::US20250051309, Example 4.128

SMILES Cc2cnc(c1cccc(S(C)(=O)=O)c1F)c(F)c2n5c(C)cc([C@H]3C[C@@H]3c4cc(Cl)c[nH]c4=O)c(Cl)c5=O

InChI Key InChIKey=OXPBOTXWIBDJSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719423   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719423(3-chloro-4-((1S,2S)-2-(5-chloro-2-oxo-1,2-dihydrop...)
Affinity DataIC50: 0.300nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM719423(3-chloro-4-((1S,2S)-2-(5-chloro-2-oxo-1,2-dihydrop...)
Affinity DataIC50: 31.4nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent