BDBM719531 1-(3-(3-chloro-3''-fluoro-4-((1S,2S)-2-(4-fluorophenyl)cyclopropyl)-5'',6-dimethy1-2-::US20250051309, Example 5.35

SMILES N#CC1CN(C(=O)c2cccc(-c3ncc(C)c(-n4c(C)cc([C@H]5C[C@@H]5c5ccc(F)cc5)c(Cl)c4=O)c3F)c2F)C1

InChI Key InChIKey=RWGAKXQRQXBVSB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719531   

TargetMitogen-activated protein kinase 14/1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719531(1-(3-(3-chloro-3'-fluoro-4-((1S,2S)-2-(4-fluorophe...)
Affinity DataIC50: 0.400nMAssay Description:In a 20 μL reaction, the compounds of various concentrations (20 nL) were pre-incubated with 0.6 nM MK2 (Abcam #ab79910) and 0.06 nM active p38α (Abc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM719531(1-(3-(3-chloro-3'-fluoro-4-((1S,2S)-2-(4-fluorophe...)
Affinity DataIC50: 29.6nMAssay Description:In a 10 μL reaction, the compounds of various concentrations (10 nL) were pre-incubated with 3 nM active p38 at (Abcam #ab271606 or in-house prepared...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent