BDBM719859 2-hydroxy-N-((5-(2-((6-methoxy- 2-(trifluoromethyl)pyrido[3,4- d]pyrimidin-4- yl)thio)acetyl)thiophen-2- yl)methyl)-N-methylacetamide::US20250051319, Compound 159::US12421222, Compound 159

SMILES COc1cc2c(SCC(=O)c3ccc(CN(C)C(=O)CO)s3)nc(C(F)(F)F)nc2cn1

InChI Key InChIKey=FCCULGFTCGVBSZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 719859   

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM719859(2-hydroxy-N-((5-(2-((6-methoxy- 2-(trifluoromethyl...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM719859(2-hydroxy-N-((5-(2-((6-methoxy- 2-(trifluoromethyl...)
Affinity DataIC50: 100nMAssay Description:Dose response testing of HDAC6 and HDAC 1 were run at Reaction Biology Corporation (RBC). Inhibition of HDAC enzymes was performed using N-terminal G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM719859(2-hydroxy-N-((5-(2-((6-methoxy- 2-(trifluoromethyl...)
Affinity DataIC50: 100nMAssay Description:NanoBRET target engagement was performed against the catalytic domain 2 (CD2) of HDAC6, with minor modifications of kit manufacturer protocol (Promeg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent