BDBM720219 preparation of 4-methyl-3-(trifluoromethyl)-7-((4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)methyl)-1,5-naphthyridin-2(1H)-one ::US20250051324, Example 19

SMILES CC1=C(C(F)(F)F)C(=O)Cc2cc(CN3CCN(c4ncc(C(F)(F)F)cn4)CC3)cnc21

InChI Key InChIKey=GCKHBHYUPAEGLF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 720219   

TargetPoly [ADP-ribose] polymerase 1(Human)
Keythera (Suzhou) Bio-Pharmaceuticals

US Patent
LigandPNGBDBM720219(preparation of 4-methyl-3-(trifluoromethyl)-7-((4-...)
Affinity DataIC50: 5.48nMAssay Description:The PARP1 assay kit was purchased from BPS Bioscience, USA, specifically the 384-well chemiluminescent assay kit (Catalog No.: #80551).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent