BDBM720656 (R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine ::US20250051362, Compound 17::US12435095, Compound 17

SMILES C[C@@H]1COCCN1c1nc(-c2ccnc3[nH]ccc23)nc2c1ccn2S(C)(=O)=O

InChI Key InChIKey=IJEDYDGSAXSVPY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 720656   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ATR/ATRIP (unknown origin) using 5-FAM-AK-17 as substrate preincubated with compound for 10 mins followed by ATP addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Shanghai Annova Biotechnology

US Patent
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.60nMAssay Description:The inhibitory activity of the compounds on ATR kinase in vitro was determined by Mobility Shift Assay at an ATP concentration of Km using Caliper EZ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Shanghai Annova Biotechnology

US Patent
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.60nMAssay Description:Experimental method: The inhibitory activity of the compounds on ATR kinase in vitro was determined by Mobility Shift Assay at an ATP concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Shanghai Annova Biotechnology

US Patent
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human ATRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 119nMAssay Description:Inhibition of human DNA-PKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine-protein kinase ATM(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of human ATMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 7.31E+3nMAssay Description:Inhibition of human ARK5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JAK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Aurora BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AMPK alpha2/beta1/gamma1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BTKMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DRAK2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABLMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LYNMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MERMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IRAK4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase BRSK2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM720656((R)-3-methyl-4-(7-(methylsulfonyl)-2-(1H-pyrrolo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BRSK2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed