BDBM72435 MLS000673104::N-(2,2-dimethoxyethyl)-1-({3-methyl-5-[(E)-2-thien-2-ylvinyl]isoxazol-4-yl}sulfonyl)piperidine-3-carboxamide::N-(2,2-dimethoxyethyl)-1-[3-methyl-5-[(E)-2-(2-thienyl)vinyl]isoxazol-4-yl]sulfonyl-nipecotamide::N-(2,2-dimethoxyethyl)-1-[[3-methyl-5-[(E)-2-thiophen-2-ylethenyl]-1,2-oxazol-4-yl]sulfonyl]piperidine-3-carboxamide::N-(2,2-dimethoxyethyl)-1-[[3-methyl-5-[(E)-2-thiophen-2-ylethenyl]-4-isoxazolyl]sulfonyl]-3-piperidinecarboxamide::SMR000314345::cid_16189378

SMILES COC(CNC(=O)C1CCCN(C1)S(=O)(=O)c1c(C)noc1\C=C\c1cccs1)OC

InChI Key InChIKey=QYLRKIHRULRGJM-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 72435   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandChemical structure of BindingDB Monomer ID 72435BDBM72435(N-(2-fluoro-5-(6-(6-methylpyridin-2- yl)-2,3-dihyd...)
Affinity DataIC50: 4.60nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details PCBioAssay