BDBM725166 (2R,3R,4R,5S)—N-(4-carbamoyl-2-methoxyphenyl)-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-6''-(trifluoromethyl)-1'',2''-dihydrospiro[pyrrolidine-3,3''-pyrrolo[3,2-c]pyridine]-5-carboxamide::US20250073340, Example 12

SMILES COc1cc(C(N)=O)ccc1NC(=O)[C@H]1N[C@H](CC(C)(C)C)[C@]2(CNc3cc(C(F)(F)F)ncc32)[C@@H]1c1cccc(Cl)c1F

InChI Key InChIKey=IQIZIUSEZUPIDM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725166   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725166((2R,3R,4R,5S)—N-(4-carbamoyl-2-methoxyphenyl)-4-(3...)
Affinity DataIC50: 103nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent