BDBM725184 (2''S,3S,4''S,5''R)-6-chloro-4''-(3-chloro-2-fluorophenyl)-N-(4-((S)-3-((2-((R)-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)piperidin-1-yl)-2-methoxyphenyl)-2''-neopentylspiro[indoline-3,3''-pyrrolidine]-5''-carboxamide::US20250073340, Example 31

SMILES COc1cc(N2CCC[C@@H](C#Cc3cccc4c3CN([C@@H]3CCC(=O)NC3=O)C4=O)C2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F

InChI Key InChIKey=FIWNKXFTVUEKIU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725184   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725184((2'S,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 6.10nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent