BDBM725198 (2''S,3S,4''S,5''R)-6-chloro-4''-(3-chloro-2-fluorophenyl)-2''-(2,2-dimethylpropyl)-N-(4-{[(3R)-1-{3-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]prop-2-yn-1-yl}piperidin-3-yl]carbamoyl}-2-methoxyphenyl)-1,2-dihydrospiro[indole-3,3''-pyrrolidine]-5''-carboxamide::US20250073340, Example 50

SMILES COc1cc(C(=O)N[C@@H]2CCCN(CC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F

InChI Key InChIKey=VVYBZQKIOPKPSI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725198   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM725198((2'S,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataIC50: 1.59nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent