BDBM725560 (S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ((difluoromethyl)sulfon- amido)-3-(1-(4- fluorophenyl)ethoxy)phenyl)- 1H-pyrazole-4- carboxamide::US20250074891, Compound 310::US12583836, Compound 310

SMILES C[C@H](Oc1cc(-c2n[nH]c(Nc3cc(C4CC4)on3)c2C(N)=O)ccc1NS(=O)(=O)C(F)F)c1ccc(F)cc1

InChI Key InChIKey=LSSOBHKTHGBZQR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 725560   

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: <10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) consist of lymphocytes, monocytes and dendritic cells that express TLR7, TLR8 and TLR9. These cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetMixed lineage kinase domain-like protein(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: <10nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: >3.00E+4nMAssay Description:Cryopreserved human PBMCs from healthy donors were thawed and resuspended in RPMI-1640 media with L-glutamine (Corning) supplemented with 10% Fetal B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: >3.00E+4nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) consist of lymphocytes, monocytes and dendritic cells that express TLR7, TLR8 and TLR9. These cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Anaxis Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 725560BDBM725560((S)-5-((5- cyclopropylisoxazol-3- yl)amino)-3-(4- ...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase assays. For most assays, kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 stra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent