BDBM725819 US20250074911, Example 42

SMILES Nc1ncc2c3c1c(-c1ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc1)nn3[C@@H]1CCC[C@H](C1)NC(=O)[C@H]1CCN1CC/C=C/2

InChI Key InChIKey=IOTRCTBOSIMCHG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 725819   

TargetTyrosine-protein kinase BTK(Human)
Crossfire Oncology Holding

US Patent
LigandPNGBDBM725819(US20250074911, Example 42)
Affinity DataIC50: 5nMAssay Description:To determine the inhibitory activity of compounds on wt-BTK enzyme activity, the IMAP® assay (Molecular Devices) was used. Compounds were serially di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Crossfire Oncology Holding

US Patent
LigandPNGBDBM725819(US20250074911, Example 42)
Affinity DataIC50: 5nMAssay Description:To determine the inhibitory activity of compounds on BTK C481S enzyme activity, the IMAP® assay (Molecular Devices) was used. Compounds were serially...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
US Patent