BDBM726081 US20250074919, Example B21

SMILES CN1CCC(Oc2nc3c(cc2C(=O)Nc2cccc(-c4cnn(C)c4)n2)CC(C)(C)O3)C1

InChI Key InChIKey=ZVBOWVCHTIUOQZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726081   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM726081(US20250074919, Example B21)
Affinity DataIC50: 74nMAssay Description:Inhibition of IRAK4 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM726081(US20250074919, Example B21)
Affinity DataIC50: 75nMAssay Description:Table 2: Prepare Ix kinase base buffer and stop buffer for testing kinases: (1) base buffer: 50 mM HEPES (pH 7.5), 0.0015% Brij-35; (2) stop buffer: ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/10/2025
Entry Details
US Patent