BDBM726497 5-[4-[(2,5-dimethyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methyl-pyridine-2-carboxamide::US20250082630, Example 2

SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c(c3C)CC(=O)C(C)=N4)CC2)cn1

InChI Key InChIKey=SMXWAJUEVBPFSM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 726497   

TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM726497(5-[4-[(2,5-dimethyl-3-oxo-4H-quinoxalin-6-yl)methy...)
Affinity DataIC50: 11nMAssay Description:Recombinant full length 6HIS tagged PARP1 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

US Patent
LigandPNGBDBM726497(5-[4-[(2,5-dimethyl-3-oxo-4H-quinoxalin-6-yl)methy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Recombinant full length 6HIS tagged PARP1 protein was diluted to 6 nM with 50 mM Tris pH 8, 0.001% Triton X100, 10 mM MgCl2, 150 mM NaCl and incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/16/2025
Entry Details
US Patent