BDBM727006 US12251379, Compound 26

SMILES CC[C@H](C)C(=O)N2CCC(NC(=O)Nc1ccc(OC(F)(F)F)c(F)c1)CC2

InChI Key InChIKey=LHRXHTKENPCGSZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 727006   

TargetBifunctional epoxide hydrolase 2(Human)
University of California

US Patent
LigandPNGBDBM727006(US12251379, Compound 26)
Affinity DataKi: <0.0500nMAssay Description:Suitable in vitro assays are described in Zeldin et al., J Biol. Chem. 268:6402-6407 (1993). Suitable in vivo assays are described in Zeldin et al., ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/22/2025
Entry Details
US Patent

TargetBifunctional epoxide hydrolase 2(Human)
University of California

US Patent
LigandPNGBDBM727006(US12251379, Compound 26)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human sEH (1 to 555 residues) using 14,15-EET as substrate preincubated for 15 mins followed by substrate addition by LC-MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Beijing Institute of Technology

Curated by ChEMBL
LigandPNGBDBM727006(US12251379, Compound 26)
Affinity DataIC50: 19nMAssay Description:Inhibition of sEH in C57BL/6J mouse brain homogenate using 14, 15-EET as substrate preincubated for 10 mins followed by substrate addition by UPLC-MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Beijing Institute of Technology

Curated by ChEMBL
LigandPNGBDBM727006(US12251379, Compound 26)
Affinity DataIC50: 19nMAssay Description:Inhibition of C57BL/6J mouse brain sEH using 14,15-EET as substrate preincubated for 15 mins followed by substrate addition by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed