BDBM728213 US20250092029, Compound AP-8-001

SMILES COc1cccc2[nH]c(C(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C(=O)COC(=O)c3c(Cl)cccc3Cl)cc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 728213   

TargetProcathepsin L(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728213(US20250092029, Compound AP-8-001)
Affinity DataIC50: 1.80nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728213(US20250092029, Compound AP-8-001)
Affinity DataIC50: 11nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetCathepsin B(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728213(US20250092029, Compound AP-8-001)
Affinity DataIC50: 24nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetProthrombin(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728213(US20250092029, Compound AP-8-001)
Affinity DataIC50: 1.00E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent