BDBM728216 US20250092029, Compound AP-8-012

SMILES O=C(CN1C(=O)[C@@H](NC(=O)c2ccc3ccccc3n2)COc2ccccc21)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COC(=O)c1c(Cl)cccc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 728216   

TargetReplicase polyprotein 1ab [3235-3246](HCoV-NL63)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728216(US20250092029, Compound AP-8-012)
Affinity DataIC50: 580nMAssay Description:Recombinant Mpro was obtained and Mpro enzymatic assays were performed as previously described (Tietjen et al., 2021). Briefly, 5 μL of 25 nM recombi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetCathepsin B(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728216(US20250092029, Compound AP-8-012)
Affinity DataIC50: 1.80E+3nMAssay Description:Assays contained 0.6 nM cathepsin B (RD systems: 953-CY-010), 25 uM Z-LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 50 mM MES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetProcathepsin L(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728216(US20250092029, Compound AP-8-012)
Affinity DataIC50: 2.31E+4nMAssay Description:Assays contained 25 pM cathepsin L (RD systems: 952-CY-010), 5 uM LR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 uL of 20 mM KPO4, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetProthrombin(Human)
The Wistar Institute of Anatomy and Biology

US Patent
LigandPNGBDBM728216(US20250092029, Compound AP-8-012)
Affinity DataIC50: 3.20E+4nMAssay Description:Assays contained 25 pM thrombin (RD systems: 1473-SE-010), 25 uM BOC—PVR-AMC, 100 nL of test compound in 100% DMSO, in at total of 10 μL of 50 mM Tri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent