BDBM728358 Preparation of (S)-3-(5-(4-((7-((1-(((7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-4-((S)-1-oxa-6-azaspiro[3.5]nonan-6-yl)pyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)cyclopropyl)methyl)-2-fluoro-7-azaspiro[3.5]nonan-2-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione ::US20250092039, Compound 214

SMILES CCc%12c(F)ccc%13cc(O)cc(c%11ncc%10c(N2CCC[C@]1(CCO1)C2)nc(OCC9(CN3CCC8(CC3)CC(F)(CN7CCN(c6ccc5C(=O)N([C@H]4CCC(=O)NC4=O)Cc5c6)CC7)C8)CC9)nc%10c%11F)c%12%13

InChI Key

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 728358   

LigandPNGBDBM728358(Preparation of (S)-3-(5-(4-((7-((1-(((7-(8-ethyl-7...)
Affinity DataIC50: 160nMAssay Description:Briefly, for the KRAS-G12V/RAF1 binding assay, 2 nM GppNHp-bound 6*His tagged KRAS-G12V proteins or 2 nM GDP-bound 6*His tagged KRAS-G12V proteins (f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
7/25/2025
Entry Details
US Patent