BDBM72950 MLS001167000::N-(4-butylphenyl)-1,3,4-trimethyl-2,6-bis(oxidanylidene)pyrimidine-5-sulfonamide::N-(4-butylphenyl)-1,3,4-trimethyl-2,6-dioxo-5-pyrimidinesulfonamide::N-(4-butylphenyl)-1,3,4-trimethyl-2,6-dioxopyrimidine-5-sulfonamide::N-(4-butylphenyl)-2,4-diketo-1,3,6-trimethyl-pyrimidine-5-sulfonamide::SMR000641295::cid_7161167

SMILES CCCCc1ccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)cc1

InChI Key InChIKey=HIZGQRWEELMMPS-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 72950   

TargetTyrosine-protein kinase JAK1(Human)
ChemWerth

US Patent
LigandChemical structure of BindingDB Monomer ID 72950BDBM72950(US12492204, Compound Oclacitinib)
Affinity DataIC50: 6.60nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2026
Entry Details PCBioAssay
TargetTyrosine-protein kinase JAK2(Human)
ChemWerth

US Patent
LigandChemical structure of BindingDB Monomer ID 72950BDBM72950(US12492204, Compound Oclacitinib)
Affinity DataIC50: 9.30nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2026
Entry Details PCBioAssay
TargetTyrosine-protein kinase JAK3(Human)
ChemWerth

US Patent
LigandChemical structure of BindingDB Monomer ID 72950BDBM72950(US12492204, Compound Oclacitinib)
Affinity DataIC50: 70nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2026
Entry Details PCBioAssay
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
ChemWerth

US Patent
LigandChemical structure of BindingDB Monomer ID 72950BDBM72950(US12492204, Compound Oclacitinib)
Affinity DataIC50: 77nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2026
Entry Details PCBioAssay