BDBM729574 US20250101020, Example 2

SMILES [2H]C([2H])([2H])N1C(=O)C2(CCC(NC(=O)NCC)CC2)c2cc(Nc3ccc4cccc(C(F)(F)F)c4n3)ncc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 729574   

LigandPNGBDBM729574(US20250101020, Example 2)
Affinity DataIC50: 100nMAssay Description:Table A, Column 1: JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Incyte

US Patent
LigandPNGBDBM729574(US20250101020, Example 2)
Affinity DataIC50: 100nMAssay Description:Table A, Column 2: JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM729574(US20250101020, Example 2)
Affinity DataIC50: 2.50E+3nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM729574(US20250101020, Example 2)
Affinity DataIC50: 2.50E+3nMAssay Description:Table A, Column 3: JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent