BDBM729575 US20250101020, Example 3

SMILES [2H]C([2H])([2H])N1c2cnc(Nc3ccc4cccc(C(F)(F)F)c4n3)cc2[C@]2(C[C@@H](CNC(=O)OC)C2)C1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 729575   

LigandPNGBDBM729575(US20250101020, Example 3)
Affinity DataIC50: 100nMAssay Description:Table A, Column 1: JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM729575(US20250101020, Example 3)
Affinity DataIC50: 2.50E+3nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent