BDBM730972 N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-methoxy-1,2-benzoxazol-3-yl}-4-(5,5-dimethyl-1,4-dioxan-2-yl)-2,6-dimethoxybenzene-1-sulfonamide::US20250122183, Example 185

SMILES COc1cc2c(NS(=O)(=O)c3c(OC)cc([C@@H]4COC(C)(C)CO4)cc3OC)noc2cc1Nc1cc(C2CC2)n[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 730972   

TargetHistone acetyltransferase KAT6A(Human)
Pfizer

US Patent
LigandPNGBDBM730972(N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-met...)
Affinity DataKi:  0.300nMAssay Description:1. Final reaction conditions are 2.5 nM KAT6A Full length enzyme, 25 μM AcCoA,2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM730972(N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-met...)
Affinity DataKi:  0.900nMAssay Description:1. Final reaction conditions are 2 nM KAT7+BRPF2+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT5(Human)
Pfizer

US Patent
LigandPNGBDBM730972(N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-met...)
Affinity DataKi:  1nMAssay Description:1. Final reaction conditions are 12.5 nM KAT5 Full length enzyme, 1 μM AcCoA, 2 μM H4 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of dilut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM730972(N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-met...)
Affinity DataKi:  1.80nMAssay Description:1. Final reaction conditions are 4 nM KAT7+JADE1+EAF6+ING5 4-protein complex, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT8(Human)
Pfizer

US Patent
LigandPNGBDBM730972(N-{6-[(3-cyclopropyl-1 H-pyrazol-5-yl)amino]-5-met...)
Affinity DataKi:  1.22E+3nMAssay Description:1. Final reaction conditions are 30 nM KAT8 Full length enzyme, 1 μM AcCoA, 2 μM H3 1-21 peptide, in a 20 μL reaction volume.2. Add 200 nL of diluted...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent