BDBM731352 US12281099, Example I-070

SMILES Cn1ccc2ccc(CNCc3[nH]c4ccccc4c3C3NC(=O)c4ccc(O)cc43)cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 731352   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM731352(US12281099, Example I-070)
Affinity DataIC50: 6.10E+3nMAssay Description:The following binding partners have been used in this assay. Biotinylated KRAS G12D protein corresponding to KRAS (amino acids 1-169, with the follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM731352(US12281099, Example I-070)
Affinity DataIC50: 1.05E+4nMAssay Description:Measurement of various protein-protein interactions was performed using the Alpha Screen technology developed by Perkin Elmer. Recombinant RAS protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent