BDBM733671 1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-[6-(pyridazin-3-ylamino)imidazo[4,5-b]pyridin-3-yl]phenyl]ethanol::US20250127780, Example 3

SMILES Cc1cc(C(F)F)nn1-c1cc(-n2cnc3cc(Nc4cccnn4)cnc32)ccc1C(C)O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 733671   

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 207nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733671(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 1.66E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent