BDBM733676 1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-[6-[(6-methylpyridazin-3-yl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]phenyl]ethanol::US20250127780, Example 8

SMILES Cc1ccc(Nc2cnc3c(-c4ccc(C(C)O)c(-n5nc(C(F)F)cc5C)c4)cnn3c2)nn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 733676   

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM733676(1-[2-[3-(Difluoromethyl)-5-methyl-pyrazol-1-yl]-4-...)
Affinity DataIC50: 3.00E+4nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent