BDBM733985 US20250127913, Compound I-87

SMILES N#Cc1ccc(F)c([C@@H](C)Nc2c(Cl)c(C)nc3cc(F)c(-c4cnc(N5CCN(C(=O)COCCOCCOCCOCCOCCOCCn6cc(CC[C@H](NC(=O)c7ccc(OCc8ccc9nc(N)nc(O)c9c8)cc7)C(=O)O)nn6)CC5)nc4)nc23)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 733985   

TargetFolate receptor beta(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM733985(US20250127913, Compound I-87)
Affinity DataKd:  0.0350nMAssay Description:Table 16: Folate receptor SPR binding assays were conducted on a Biacore 8K instrument (Cytiva) using biotinylated folate receptor beta (Acro Biosyst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetFolate receptor beta(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM733985(US20250127913, Compound I-87)
Affinity DataIC50: 8nMAssay Description:Table 15: Folate receptor binding was measured in black 96-well plates using a fluorescence polarization assay. A fluorescent probe consisting of a f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM733985(US20250127913, Compound I-87)
Affinity DataIC50: 22nMAssay Description:Table 15: TNFα binding was measured in black 96-well plates using a time-resolved FRET assay using a previously described fluorescence acceptor TNFα ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details
US Patent