BDBM734005 US20250127913, Compound I-91

SMILES Cc1nc2cc(F)c(-c3cnc(N4CCN(C(=O)COCCn5cc(COCCOCCOCCOCCNC(=O)CC[C@H](NC(=O)[C@H]6CC[C@H](NCc7cnc8nc(N)nc(O)c8n7)CC6)C(=O)O)nn5)CC4)nc3)nc2c(N[C@H](C)c2ccccc2F)c1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 734005   

TargetFolate receptor beta(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM734005(US20250127913, Compound I-91)
Affinity DataKd:  0.201nMAssay Description:Table 16: Folate receptor SPR binding assays were conducted on a Biacore 8K instrument (Cytiva) using biotinylated folate receptor beta (Acro Biosyst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details

TargetTumor necrosis factor(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM734005(US20250127913, Compound I-91)
Affinity DataIC50: 17.5nMAssay Description:Table 15: TNFα binding was measured in black 96-well plates using a time-resolved FRET assay using a previously described fluorescence acceptor TNFα ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details

TargetFolate receptor beta(Human)
Lycia Therapeutics

US Patent
LigandPNGBDBM734005(US20250127913, Compound I-91)
Affinity DataIC50: 138nMAssay Description:Table 15: Folate receptor binding was measured in black 96-well plates using a fluorescence polarization assay. A fluorescent probe consisting of a f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/25/2025
Entry Details