BDBM736196 (4S,4''S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-isoquinolyl)-2-[(6-methylpyrimidin-4-yl)methyl]spiro[3H-isoquinoUne-4,3''-pyrrolidine]-1,2,-dione::WO2025125695, Example 4

SMILES CCNC[C@H]1CN(c2cncc3ccccc23)C(=O)[C@@]12CN(Cc1cc(C)ncn1)C(=O)c1ccc(Cl)cc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 736196   

TargetReplicase polyprotein 1ab(2019-nCoV)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 1nMAssay Description:The inhibition of the SAR-CoV-2 MPro Enzyme was measured by the method of Mesecar et al.20: The fluorescence of the cleaved FAM peptide (excitation 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetTransmembrane protease serine 2(Human)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  19nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetAngiotensin-converting enzyme 2(Human)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataEC50:  31nMAssay Description:Four thousand HeLa-ACE2 or Vero-TMPRSS2 cells (BPS Bioscience) were seeded into 96-well plates in DMEM (10% FBS) and incubated for 24 hours at 37°C, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695

TargetReplicase polyprotein 1ab(SARS-CoV)
Medchemica

WIPO
LigandPNGBDBM736196((4S,4'S)-6-chloro-4,-[(ethylamino)methyl]-1,-(4-is...)
Affinity DataIC50: 51nMAssay Description:The inhibition of the MERS-CoV-2 MPro Enzyme was measured by an analogous method to that of Mesecar et al.20 The fluorescence of the cleaved FAM pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/28/2025
Entry Details
WIPO WO2025125695