BDBM736420 US20250134882, Example 4

SMILES CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 736420   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PTPN2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human recombinant PTPN2 incubated for 20 mins by mobile shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human PTPN2 extracted from Escherichia coli BL21 (DE3) by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human PTPN2 using DiFMUP as substrate by fluorescence based phosphatase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein phosphatase N2 [1-387](Homo sapiens (Human))
Nerio Therapeutics

US Patent
LigandPNGBDBM736420(US20250134882, Example 4)
Affinity DataIC50: 7.08E+4nMAssay Description:Compound activity was determined in an in vitro enzymatic assay using untagged, full-length human PTPN2 (TC45) (1-387) protein. PTPN2 was produced in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent