BDBM738203 Preparation of (S)-2,4-difluoro-N-(5-(4-(4-(2-fluoroacryloyl)-2-methylpiperazin-1-yl)quinazolin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide::US20250145589, Example 9

SMILES C=C(F)C(=O)N1CCN(c2ncnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)[C@@H](C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738203   

LigandPNGBDBM738203(Preparation of (S)-2,4-difluoro-N-(5-(4-(4-(2-fluo...)
Affinity DataIC50: 0.560nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738203(Preparation of (S)-2,4-difluoro-N-(5-(4-(4-(2-fluo...)
Affinity DataIC50: 9.05nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent