BDBM738252 2,6-difluoro-N-(5- (4-(2-(2- fluoroacryloyl)- 2,6- diazaspiro[3.4] octan-6- yl)quinazolin-6- yl)-2- methoxypyridin-3- yl) benzenesulfonamide::US20250145589, Example 48

SMILES C=C(F)C(=O)N1CC2(CCN(c3ncnc4ccc(-c5cnc(OC)c(NS(=O)(=O)c6c(F)cccc6F)c5)cc34)C2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738252   

LigandPNGBDBM738252(2,6-difluoro-N-(5- (4-(2-(2- fluoroacryloyl)- 2,6-...)
Affinity DataIC50: 0.630nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738252(2,6-difluoro-N-(5- (4-(2-(2- fluoroacryloyl)- 2,6-...)
Affinity DataIC50: 13.2nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent