BDBM738279 Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-(4-(3-(methylsulfonyl)acryloyl)piperazin-1-yl)quinazolin-6-yl)pyridin-3-v)benzenesulfonamide::US20250145589, Example 75

SMILES COc1ncc(-c2ccc3ncnc(N4CCN(C(=O)CCS(C)(=O)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 738279   

LigandPNGBDBM738279(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 0.780nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738279(Preparation of (E)-2,4-difluoro-N-(2-methoxy-5-(4-...)
Affinity DataIC50: 31.2nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent