BDBM738285 (E)-N-(2- chloro-5- (4-(4-(4- oxopent-2- enoyl) piperazin-1- yl)quinazolin- 6-yl)pyridin- 3-yl)-2,6- difluoro- benzene- sulfonamide::US20250145589, Example 84

SMILES CC(=O)/C=C/C(=O)N1CCN(c2ncnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5c(F)cccc5F)c4)cc23)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 738285   

LigandPNGBDBM738285((E)-N-(2- chloro-5- (4-(4-(4- oxopent-2- enoyl) pi...)
Affinity DataIC50: 0.830nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kα with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

LigandPNGBDBM738285((E)-N-(2- chloro-5- (4-(4-(4- oxopent-2- enoyl) pi...)
Affinity DataIC50: 7.60nMAssay Description:The ADP-Glo™ kinase assay was used to assess the inhibition of PI3Kδ with our compounds. The utilized proteins and assay reagents were obtained from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandPNGBDBM738285((E)-N-(2- chloro-5- (4-(4-(4- oxopent-2- enoyl) pi...)
Affinity DataIC50: 268nMAssay Description:The HTRF KRASG12C/SOS1 Binding Assay was used to measure the interaction between KRASG12C and SOS1 proteins, and evaluate the enzymatic activity of c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent